The burning sensation in the esophagus may be GERD, functional dyspepsia, or angina, and should be treated according to the cause. For GERD, give omeprazole, etc. For functional dyspepsia, give doxycycline tablets, etc. 1. Gastroesophageal Reflux Disease (GERD): Gastric acid and bile reflux into the esophagus causes damage to the esophageal mucosa, resulting in a burning sensation in the esophagus, and the medications that should be taken include acid inhibitors such as omeprazole, rabeprazole and other proton pump inhibitors, antihistamines such as famotidine, ranitidine, and gastrointestinal stimulant medications, such as mosapride, domperidone, and so on. 2. Functional dyspepsia: overeating, eating too much greasy food, resulting in indigestion, food accumulation in the gastrointestinal tract, upward reflux into the esophagus caused by esophageal burning sensation, should be applied to omeprazole and other acid-suppressing drugs, doxepin and other gastrointestinal dynamics of the drug, as well as to help digestion of the drug, including multi-enzymes and so on. Burning sensation in the esophagus can be caused by many reasons, and angina can not be ruled out, it is recommended to go to the hospital in a timely manner, under the guidance of the doctor according to the cause of the treatment prescribed by the doctor.