The common causes of high transaminase include non-pathologic factors, liver and gallbladder diseases, and other diseases, etc. Depending on the causes, it can generally be lowered by removing the factors causing the elevation, treating the etiologic factors, and applying liver-protecting medications, and the rate of lowering varies depending on the condition. 1. Non-pathological factors: physiological elevation (late night, strenuous exercise, etc.); toxic effects of various drugs, food or exposure (e.g., antifungal drugs, some antibiotics, food poisoning, etc.), which need to be eliminated in time, and liver-protecting drugs (e.g., reduced glutathione) should be applied when necessary. 2. Hepatobiliary diseases: fatty liver, hepatitis, cirrhosis, active stage of hepatocellular carcinoma, alcoholic liver disease, biliary tract diseases (e.g. cholecystitis, acute attack of cholelithiasis). Etiologic treatment is needed, such as alcohol cessation, antiviral, repair of liver damage, and application of liver-protecting drugs (e.g., reduced glutathione). 3. Other diseases: immune diseases (e.g. dermatomyositis, tumors), serious infections (e.g. pneumonia, tuberculosis, ischemic disease), heart disease (acute myocardial infarction, myocarditis, heart failure, etc.), need to treat the underlying disease, but also the application of liver-protecting drugs (e.g. reduced glutathione). High transaminases may also have other causes, it is recommended to consult a doctor in time, under the guidance of the doctor to determine the cause of the standardized treatment, to avoid adverse consequences.