Seronegative spondyloarthritis, or spondyloarthritis, mainly includes ankylosing spondylitis, psoriatic arthritis, enteropathic arthritis, reactive arthritis, juvenile spondyloarthritis, and undifferentiated spondyloarthritis. Spondyloarthritis is a group of immune, inflammatory diseases that are predominantly arthropathies with multi-system involvement. The main diseases in this group include: ankylosing spondylitis, psoriatic arthritis, enteropathic arthritis, reactive arthritis, juvenile spondyloarthritis, and undifferentiated spondyloarthritis. The cause of the disease is unclear. Current research suggests that environmental factors and immune abnormalities due to genetic susceptibility are important factors in the development of spondyloarthritis. The diseases in this group have the following common features: a tendency toward familial aggregation; varying degrees of correlation with the HLA-B27 allele; many commonalities and overlaps in clinical manifestations; a rheumatoid factor positivity rate similar to that of the normal population; varying degrees of sacroiliac arthritis; and pathological changes that are predominantly found around the ends of the tendons and at the sites of ligamentous attachments to the bone (adhesion point inflammation). If there is seronegative spondyloarthritis, it is recommended to go to the hospital in time for examination to clarify the diagnosis and carry out targeted treatment as early as possible.