Yellow eyes and weight loss may be related to physiological factors and pathological factors such as acute liver injury. 1. Physiological factors: mainly because of the failure to ensure sufficient sleep in daily life. Long-term sleep deprivation may lead to weight loss, the eyes can not get enough rest may lead to redness and swelling of the eyes, eyeball congestion, fat deposits in the conjunctiva can lead to the eyes look a little yellow. 2. Pathological factors: such as acute liver injury, including acute drug liver injury, acute liver failure, etc., hyperbilirubinemia can occur, resulting in yellowing of the skin and sclera. Patients with acute liver injury may experience nausea and vomiting, thus leading to weight loss. If yellowing of the eyes and weight loss occur, it is recommended to go to the hospital in time to improve the examination and take appropriate treatment according to the cause.