Rectal cancer of low and middle differentiation can be treated with medication and surgery under the guidance of doctors. The malignancy degree of cancer is clinically divided into four types, and middle and low differentiated cancer belongs to a category of tumor with higher malignancy degree. 1. Drug treatment: Low-differentiated rectal cancer is a malignant tumor located in the rectum, patients can use irinotecan, oxaliplatin and other drugs under the guidance of doctors for treatment, after using them, patients may have diarrhea, nausea, vomiting and other symptoms, and patients who are allergic to oxaliplatin or other platinum compounds are forbidden to use this drug. 2. Surgery: If the patient is an early stage of middle or low differentiated cancer, radical surgery can be performed to directly remove the rectum, to completely remove the cancer cells from the body, and to control the growth of the tumor so as to achieve a radical cure. After surgery, patients should go down to the ground as early as possible, pay attention to dietary regulation, prohibit spicy and stimulating food, and actively cooperate with doctors for postoperative care and radiotherapy. Once diagnosed, patients should go to regular hospitals as soon as possible for consultation and treatment under the comprehensive assessment of the condition by professional doctors.