A positive DOB value indicates H. pylori infection, which is highly prevalent and can be seen in a variety of gastric diseases, such as chronic non-atrophic gastritis, chronic atrophic gastritis, gastric ulcer, and gastric cancer. If H. pylori infection is present, anti-infective treatment is needed, otherwise it will aggravate the progression of the disease. And the most common method to eradicate H. pylori is two antibiotics, because an antibiotic is difficult to eradicate, such as gastric mucosal protective agents and proton pump inhibitors, the combination of the above drugs applied for two weeks after a month of discontinuation, re-check the carbon 13 or carbon 14 breath test, if the DOB is negative at this time, it is eradicated, if it is considered positive need the next round of treatment. During the treatment period, care should be taken to sterilize dishes, share utensils, etc.