Atypical squamous cell ASC-US refers to atypical squamous cells of unclear significance, not necessarily cervical cancer. Atypical squamous cell ASC-US is one of the report findings of TCT for cervical exfoliative cytology, which indicates that atypical cells are seen at the cytologic level, but the significance is not clear enough to be definitively a pre-cancerous lesion or even a cancerous cell, so it may not necessarily be cervical cancer, and further tests, such as colposcopy and cervical biopsy, are needed. Patients with atypical squamous cell ASC-US should actively consult the doctor for a clear diagnosis. Do not self-medicate to avoid adverse results, but standardize the treatment under the guidance of physicians according to the condition.