With the popularization of medical knowledge, more and more patients are worried about the malignancy of their moles and visit plastic surgery to have them removed. So, should moles be removed or not? What kind of moles must be removed? How to self-monitor and determine whether a mole has become malignant? 1.Everyone has different numbers of moles on the body surface, which are found at birth or grow out later, and on average, there are about 20 moles in each person’s body. The majority of moles do not become malignant, and only a very small number of moles become malignant to melanoma. In the past, the malignancy of melanoma was considered to be quite high, so its treatment was quite “cruel” and amputation of the lower limb was performed when the toe was found to be malignant. Currently, with more experience in treatment and technological advances, the treatment of malignant nevi is also progressing. Therefore, there is no need to worry too much about the possibility of malignant transformation of moles; 2. The signs of malignant transformation of moles are as follows: A. The growth rate is obviously accelerated; B. Local symptoms such as itching and pain appear; C. Local rupture appears; D. The boundary of moles is unclear and infiltrative growth. Therefore, self-monitoring can be carried out according to the above characteristics, but of course, there is no “absolute” medical condition, and malignant nevus may not show the above symptoms, and even if the above symptoms appear, malignant nevus may not necessarily appear; 3. They mainly include the following, repeated friction, ultraviolet radiation, mucous membrane sites, etc. Therefore, nevi on the palms of the hands, soles of the feet, and mucous membrane sites (lips, mouth, and vulva) on the body must be removed, and repeated friction sites, such as male beard sites, waistbands, and bra belt sites should also be removed. Facial moles should also be removed because they receive ultraviolet radiation and affect the aesthetics; 4. Should moles be excised or removed by laser? After excision, the specimen can be sent for pathological examination to obtain accurate results, which is the safest way; however, surgical scar will be left after excision. Plastic surgery can hide the scar to the greatest extent, but it cannot remove it completely. Laser mole removal is suitable for superficial and small moles. The advantage is that as long as the stripping depth is properly mastered, there is basically no trace left after healing. Therefore, both have their own advantages and should be analyzed specifically for each patient’s specific situation.