Traumatic skull injury will not only affect the patient’s quality of life, but also lead to death or disability, so the best time for skull repair must be as early as possible when the skull defect, depending on the patient’s neurological specifics and the cause of the skull defect. If the patient’s skull defect is due to trauma, such as: traffic accident, fall from height, violent blow, etc. resulting in skull defect, and the patient’s wound is relatively clean open skull comminuted fracture without cranial hypertension patients can do skull repair surgery at that time, such as more patients due to disease, for example: cerebrovascular disease severe cranial trauma, etc., due to intracranial hypertension debridement decompression, patients need to be in about three months time and then cranial bone repair. The final time for cranial repair still needs to be evaluated based on the patient’s body to see if the patient is suitable for surgery. If the patient is suitable for cranial defect repair, which repair material is good for cranial repair? The choice of repair material for cranial bone repair is crucial, because good repair material can reduce the patient’s injury, and can also improve the success rate of surgery and reduce some postoperative complications. The new PEEK material is currently used for clinical cranial bone repair, and the 3D printed cranial bone used for PEEK material has a variety of advantages such as good biological compatibility and heat and ion radiation resistance. “It fits better than traditional titanium materials, and it will not be affected by passing airport security or undergoing medical examinations such as MRI, and it is harder and safer in daily life.