The mother-to-child interruption of hepatitis B includes the mother-to-child interruption during pregnancy and the mother-to-child interruption after the child is born, as follows: a. Check the hepatitis B virus quantification when the pregnant woman is pregnant, if the hepatitis B virus quantification reaches (10^8)-(10^9) IU/ml, it is recommended that the pregnant woman start oral tenofovir antiviral therapy at 24 weeks of pregnancy. -(10^7) IU/ml, it is recommended to start antiviral treatment at 28 weeks of pregnancy, and if the pregnant woman’s hepatitis B viral load is 10^5 IU/ml, it is recommended to start antiviral treatment at 30 weeks. Second, the child should be injected with hepatitis B immunoglobulin and hepatitis B vaccine after birth, which should be done within 24 hours and the earlier the better.