It is not possible to compare which statin is less damaging to liver and kidney function, and liver and kidney function damage takes into account the dose of the drug and the sensitivity of the patient. Most statins are metabolized by the liver and may cause some impairment of liver function after taking a statin, while some are excreted by the kidneys and cause relatively little damage to the kidneys. Any statin may cause impairment of liver and kidney function, and it is not possible to assess which is the least damaging. The damage of statins to liver and kidney function is related to the dose of the drug, with the higher the dose the more severe the damage. It is also related to the sensitivity of the patient to the drug, and in some patients the liver impairment may be immune-induced. The main role of statins is to lower cholesterol, the process of taking drugs, pay attention to monitoring liver and kidney function, if there is nausea, vomiting, jaundice, or abnormal elevation of ammonia enzyme, we should promptly go to the hospital. Specific medication should follow the doctor’s instructions.