In most cases, the physiological pain of the extraction trauma will start about 1 hour after the wisdom tooth extraction. The most common anesthetic used for wisdom tooth extraction is lidocaine, which has anesthetic effect for about 90-120 minutes, and the anesthetic effect may be prolonged if paracetamol is added. In addition to the commonly used lidocaine, the drugs that are more commonly used in the clinical practice for tooth extraction are epinephrine, also known as bilirubin and scanduni, which are applied to remove teeth. In general, the action time of these three drugs is around 1-2 hours, so the pain will start about 1 hour after the extraction of the tooth.