The main ingredient of Estradiol Valerate, Tegretol can be used in combination with progestins to establish an artificial menstrual cycle and is used to supplement symptoms of estrogen deficiency mainly associated with natural or artificial menopause, like vasoconstriction disorders such as hot flashes, and genitourinary tract trophic disorders such as vulvovaginal atrophy, dyspareunia and urinary incontinence. It also includes psychiatric disorders, such as sleep disorders and debility. Some patients should be prohibited from using estradiol valerate, so care must be taken when administering the drug first, such as pregnant and lactating women, undiagnosed vaginal bleeding, suspected breast cancer, patients with known breast cancer, as well as precancerous lesions, malignant tumors, previous history of liver tumors, severe liver disease, acute arterial thromboembolic disease, active deep vein thrombosis, thromboembolic disease, patients with venous Estradiol valerate should be contraindicated in patients with high risk factors for venous or arterial thrombosis, and in patients with severe hypertriglyceridemia, and should be carefully evaluated before use.