There is no strict requirement to do skin test when applying amitranan, amitranan is a β-lactam antibiotic medication is relatively safe, but does not exclude allergy, especially some patients have a history of penicillin allergy, or usually is allergic to the body of the patient, the application of amitranan may be allergic to the safety of medication some hospitals also recommend skin test. Amitranan is widely used in the clinic, it has good antibacterial effect on gram-negative bacilli such as Escherichia coli, Klebsiella, Haemophilus influenzae, Pseudomonas aeruginosa, etc. It can be used for skin and soft tissue infections, respiratory infections, genitourinary infections caused by sensitive bacterial infections, and antibiotics can be applied only if the bacterial infection is clear, and it is recommended to apply the drug under the direction of a doctor. Treatment. The first time the application of amitranam start to pay attention to the infusion speed should not be too fast, and observe the patient’s condition to see if there is any allergic manifestations, once the patient appears allergic to the situation should be dealt with in a timely manner.