Lung adenocarcinoma bone metastasis needs reasonable choice of chemotherapy according to patient’s specific condition, not always chemotherapy. Lung adenocarcinoma bone metastasis belongs to advanced stage, which is clinically considered difficult to be cured, so chemotherapy should be applied until the disease progresses. For patients with better chemotherapy effect and more stable condition, prolonged chemotherapy can be considered, which can not only achieve better therapeutic effect, but also give patients a longer buffer time. Patients who are unable to tolerate repeated chemotherapy for a long period of time or are in poor condition should not be forced to undergo chemotherapy, and such patients may not benefit from it. In addition to chemotherapy, lung adenocarcinoma can also benefit from targeted and immunotherapy, especially targeted therapy, which is better tolerated, so the treatment plan should be chosen reasonably according to the specific conditions of patients.