Inflammation of the descending part of the duodenum has been associated with Helicobacter pylori, making screening necessary. H. pylori infection is associated with gastroduodenal diseases. H. pylori tends to parasitize the sinus area of the stomach, and when stomach acid is overproduced, H. pylori enters the duodenum, which may lead to inflammation or even ulcers in the duodenal bulb. Patients with duodenal ulcers are often associated with H. pylori infection. H. pylori tests such as carbon 13 urea breath test, C14 breath test, H. pylori antibody test, and saliva test panel test can be performed in case of duodenal descending inflammation in order to rule out possible risks and screen for the presence of H. pylori. Screening for H. pylori is recommended for patients with symptomatic disease of gastritis or duodenitis. Patients who are positive for H. pylori are recommended to be treated with quadruple therapy such as omeprazole, amoxicillin, bismuth pectin, and clarithromycin under the supervision of a physician, which should be taken according to the doctor’s recommendation and as prescribed by the physician. Inflammation of the descending duodenum is recommended to be standardized under medical supervision.