If you are at moderate risk for Down’s syndrome, it is best to have a non-invasive DNA test. The accuracy of Down’s syndrome screening can only reach 65%. If the risk is moderate, the possibility of fetal abnormality can be considered, but it cannot be accurately determined, either by amniocentesis or by non-invasive DNA testing. Non-invasive DNA is a test that determines the risk of trisomy 21, trisomy 18 and trisomy 13 by taking the fetal DNA from the mother’s blood. If the risk of non-invasive DNA is high, amniocentesis is recommended. Amniocentesis can accurately determine whether the fetus has genetic problems.