Sleeping up and feeling sore and weak is usually caused by the following factors: First, the most common factor is the initial stage of viral cold, when the infection will feel sore and weak, because the virus releases inflammatory mediators in the body, inflammatory mediators will make the nerve roots around the self-conscious sore and weak. Second, the body ion disorders and metabolic disorders, usually due to hypokalemia, hyponatremia will also appear the above clinical symptoms and performance. Third, coronary atherosclerotic heart disease, myocardial ischemia, in coronary heart disease myocardial ischemia will be conscious of chest tightness, shortness of breath, peripheral pain, weakness, accompanied by peripheral fatigue clinical symptoms and clinical manifestations, usually due to myocarditis, cardiomyopathy and pericarditis, dilated heart disease, etc., will appear the above clinical symptoms and manifestations.