Numbness of the hands and feet during sleep, if the patient is bilateral, first consider the cervical spine, lumbar spine disease. Mostly seen in middle-aged and elderly patients, due to osteoporosis, as well as cervical disc and lumbar disc herniation, leading to the dural sac during sleep at night, as well as nerve root compression, the patient can appear numbness of the hands and feet, in the morning when the activity can be significantly reduced. Tingling in the hands and feet during sleep, if one side of the hands and feet tingling, clinically alert to ischemic cerebrovascular disease, also known as transient ischemic attack, the patient’s symptoms seldom last more than an hour, it is recommended that the patient consult the Department of Neurology, and if necessary, need to be given to the antiplatelet aggregation as well as the activation of blood stasis and other treatments. In addition, numbness of the hands and feet during sleep can also be seen in some patients with poor peripheral blood circulation, such as arteriosclerosis occlusive disease of the lower limbs, or due to poor glycemic control in diabetic patients, patients are prone to numbness and coldness of the hands and feet, which is mainly due to peripheral nerve damage.