The specific causes and pathogenesis of lupus erythematosus have not yet been fully clarified, and current research suggests that it is related to factors such as the environment, heredity, sex hormones, ultraviolet rays, infections, pregnancy, trauma, and mental stress. Lupus erythematosus is categorized as systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE) in terms of histopathology and clinical manifestations, and the pathogenesis and causes of the disease are still unknown. Among them, patients with SLE show familial clustering of the disease, and are more common in women of childbearing age. Ultraviolet radiation may also lead to an increase in immunogenicity of skin tissues and exacerbate or induce lupus erythematosus. In addition, pathogenic infections such as EBV, streptococcus, etc., may induce or exacerbate lupus erythematosus, as well as isoniazid, penicillin, and some biologics may induce drug-induced lupus. In addition, endocrine disorders, pregnancy, trauma, cold stimulation, overwork, lack of rest, mental tension, mental stress and other factors may also be associated with the development of lupus erythematosus. Patients diagnosed with lupus erythematosus are advised to go to the rheumatology and immunology departments of regular hospitals for detailed consultation and active cooperation in treatment.