Myeloma is also known as multiple myeloma. The prognosis of stage III is generally poor, but it can be treated by systematic treatment to improve the quality of survival and prolong life, and can be treated by targeted treatment, chemotherapy and stem cell transplantation. 1. Targeted treatment: when bone disease occurs, intravenous or oral application of bisphosphonates can be used for treatment, such as disodium pamidronate or clodronic acid. When hypercalcemia is caused, glucocorticoids or calcitonin can be selected according to the actual situation of the patient for treatment, such as dexamethasone. Repeated infections or more serious infections, can consider the use of immunoglobulin for treatment, during the treatment to prevent fungal infections. 2. Chemotherapy: If the patient is relatively young but there is no indication for surgery, chemotherapy program can be adopted, and the commonly used chemotherapy drugs include melphalan, bortezomib and prednisone. 3. Stem cell transplantation: patients with multiple myeloma can receive autologous hematopoietic stem cell transplantation when the disease is in remission. When multiple myeloma develops to stage III, you must cooperate with doctors to carry out effective treatment, usually have good emotional management, and consult doctors in time when any uncomfortable symptoms appear.