Zhi Bai Di Huang Wan and Zuo Gui Wan have different efficacy, different application and different ingredients. 1. Different effects: Zhi Bai Di Huang Wan has the effect of nourishing yin and lowering fire; Zuo Gui Wan has the effect of nourishing the kidney and tonifying yin. 2. Application: Zhi Bai Di Huang Wan is clinically used for the treatment of yin deficiency and fire exuberance, hot flashes and night sweating (sweating abnormally after going to sleep and stopping after waking up), dry mouth and sore throat, tinnitus and spermatorrhea, and short and red urination (small amount of urination, dark yellow color); Zuo Gui Wan is clinically used for the treatment of true yin deficiency, lumbar soreness and weakness of the knees, night sweating, and fatigue of God (lack of mental energy), and dryness of the mouth, and other diseases. 3. Different ingredients: Zhi Bai Di Huang Wan is composed of Zhi Mu, Huang Bai, Radix Rehmanniae Praeparata, Cornu Cervi Pantotrichum, Mudan Pi, Chinese yam, Poria, Zuogui Pill is composed of Radix Rehmanniae Praeparata, Cuscuta sinensis, Cortex Cuscutae, Cortex Pantotrichum, Cornu Cervi Pantotrichum, Chinese yam, Cornu Cervi Pantotrichum, and Chinese wolfberry. In addition, Zuo Gui Wan is contraindicated for pregnant women and forbidden for children; its adverse reactions and contraindications are not clear. The adverse reactions and contraindications of Zhi Bai Di Huang Wan are not clear. After the discomfort should be timely medical treatment, under the guidance of the physician’s diagnosis and selection of medication, not self-medication, so as not to delay the condition.