Cefotaxime sodium can treat Helicobacter pylori, but it is not a recommended drug of choice and it is difficult to eradicate Helicobacter pylori with one drug alone. Cefotaxime sodium is a third-generation cephalosporin with broad-spectrum antibacterial effects. It has antibacterial effect on gram-negative bacteria such as Escherichia coli, Klebsiella spp, Salmonella spp, Proteus mirabilis, Proteus vulgaris, etc., as well as gram-positive bacteria such as Streptococcus pneumoniae, Streptococcus haemolyticus and so on. Cefotaxime sodium adverse reactions include rash, phlebitis, drug fever, nausea, vomiting, diarrhea, and loss of appetite. The drug is contraindicated in people who are allergic to cephalosporins, or have a history of penicillin anaphylaxis. Helicobacter pylori belongs to gram-negative bacilli, so the use of cefotaxime also has a therapeutic effect, but Helicobacter pylori alone is difficult to eradicate the drug, the general choice of the preferred amoxicillin, clarithromycin, metronidazole in the two antibiotics combination therapy. The presence of Helicobacter pylori infection, should be standardized treatment under the guidance of a doctor, not blindly self-medication.