Making thyroid nodules disappear should be treated according to the cause. Currently, there are many clinical diseases that cause thyroid nodules, including systemic inflammation, localized inflammation of the thyroid gland, hyperthyroidism, and thyroid cancer. Thyroid nodules caused by localized lymph node enlargement due to inflammation can be treated with anti-inflammatory and antibacterial drugs. Thyroid nodule enlargement due to hyperthyroidism can be treated with iodination along with methimazole, and the combination of these two treatments can improve the effectiveness of the treatment. Before treatment, the localized cells are prone to differentiation, which can lead to thyroid cancer. In this case, surgery should be performed in time to remove part of the enlarged tissue to avoid the spread of cancerous factors. Surgery can also be considered for the first two diseases.