Sperm allergy is relatively rare clinically, but it does occur in a small percentage of people. Semen allergy is mainly due to an allergic reaction caused by a woman’s exposure to her partner’s semen after initial intercourse, because semen itself is an antigenic component that may cause an allergic reaction when it enters a woman’s body. Clinical manifestations vary from person to person and can manifest as edema of the vagina and perineum, itching of the lower body, and some people will have a runny nose, sneezing, and even hives, rashes, and sore throats. The time of occurrence is usually about ten minutes after ejaculation, some people appear about 2-3 hours after ejaculation. The treatment is currently mainly instrumental contraception, using condoms to prevent semen from entering the woman’s body, and also oral anti-allergy drugs, such as paracetamol, benadryl and other drugs for treatment.