High flux dialysis can effectively clear large and medium molecule toxic substances, but there are some disadvantages, as follows: 1, anti ultrafiltration phenomenon, due to the large filtration coefficient of high flux dialyzer, the filter membrane pore is large, and water and solute are very easy to pass through. When the pressure on the blood side is low due to the high flow of dialysate, the pressure on the dialysis side is greater than that on the blood side, which results in the phenomenon of anti ultrafiltration, so that the weight of dialysis patients after dialysis is increased instead; 2, endotoxin into the blood, the aperture of the high-flux dialyzer is large, and endotoxin is relatively easy to enter into the bloodstream through the membrane of the dialyzer, which causes the patients to have a febrile reaction; 3, the incidence of hypotension is obviously increased, and the high-flux dialysis is prone to make a large amount of Water and solutes are rapidly filtered out, thus increasing the risk of hypotension. It also results in the loss of nutrients, such as proteins and amino acids, which aggravates the incidence of hypotension.