After the application of antidepressant drugs, generally 3-7 days to start the effect, to achieve a more satisfactory effect, the self can feel the situation, it usually takes 20-30 days. Application of antidepressant drugs is an adjustment stage, 3-5 days may need to adjust the dose, gradually increased to the therapeutic dose, 10-15 days to increase to the therapeutic dose, and then half a month, the total course of treatment for a month or so may achieve a better effect. Therefore, if you just apply antidepressant drugs, you should be psychologically prepared, must adhere to the medication, and regularly go to the hospital for follow-up, especially in the early stage, the need for doctors to help gradually adjust the dose of the drug, do not say that just 3-5 days feel no effect on the discontinuation of the antidepressant drug application treatment needs a process.