Insulin sensitizers refer to thiazolidinediones hypoglycemic drugs, commonly used are rosiglitazone, pioglitazone, etc. The main mechanism of action of these drugs is to reduce insulin resistance, increase insulin sensitivity, and make the effect of insulin enhanced. They can also achieve the efficacy of lowering blood glucose by increasing the utilization of glucose by peripheral tissues such as muscles and bones. It can be applied alone or together with other hypoglycemic drugs and insulin. It is more suitable for type 2 diabetic patients with significant insulin resistance, but cannot be used for type 1 diabetic patients, pregnant women, lactating women and children. Its main adverse effects include edema and weight gain, but it should not be applied or applied with caution in patients with heart disease, liver disease, or heart failure.