Inability to hold urine may be related to stress incontinence, acute cystitis, overactive bladder syndrome, prostate enlargement and other factors. 1. Stress incontinence: it may be related to estrogen deficiency, excessive obesity and other factors, which can lead to inability to hold urine and leakage when performing some actions with increased abdominal pressure, such as violent coughing and sneezing. 2. Acute cystitis: may not pay attention to the lower body hygiene, acute cystitis bladder mucosal sensitivity is too high, urine on the bladder mucosa caused by irritation, can lead to hold urine, there may also be urge incontinence, accompanied by urinary pain, urinary frequency, urgency and other symptoms. 3. Overactive bladder: due to abnormal bladder function, frequent contractions may occur, which can lead to incontinence, incontinence, manifested as the appearance of the urge to urinate after it is too late to urinate, urine will flow out on its own, accompanied by frequent urination, urinary urgency, urinary incontinence and other symptoms. 4. Prostatic hyperplasia: mainly in the elderly male group, as the gland increases in size, it will seriously oppress the posterior urethra, leading to an increase in urine in the bladder, causing incontinence, which may be accompanied by difficulty in urination, weakness in urination and other symptoms, and in severe cases, it can cause urinary retention. If you have trouble holding in your urine, it is recommended that you seek medical attention as soon as possible for examination and treatment to avoid aggravation of the lesion.