As long as it is not sleep at night even if it is staying up late, regardless of whether the circadian life forms a rule, only the formation of the rule is less harmful to the human body. The result of human adaptation to the environment is to work during the day and rest at night, the body is also naturally adapted to the rule of sleeping at night, which belongs to the internal rhythm of life movement, we will call it the biological clock. In addition, there are regularities in human physiological activities, such as human growth hormone is mostly secreted at night during sleep; the liver uses the time when the human body rests quietly at night to accelerate the production of substances needed by the body and begin to discharge harmful substances; the whole body muscles reach a relaxed state, and most organs of the body will work slowly and enter a resting state. But the body is in a long-term overload, day and night reversal of work, easy to cause the body endocrine disorders, dizziness, headache, slow reaction, memory loss and other performance, may also appear the body immune system decline, common mouth ulcers, repeated fever, coughing, coughing, etc., and serious will induce cardiovascular disease. If the patient already has a disturbed biological clock, it is recommended to first make changes in lifestyle habits and then consider medication, such as exercising during the day in an amount suitable for you to not feel uncomfortable, which can strengthen your body as well as increase your body’s fatigue and enhance the effect of sleep aid. Avoid excessive mental excitement before going to bed, and look less at cell phones and electronic products. If the improvement of lifestyle habits is ineffective, you need to actively cooperate with the treatment.