Ibuprofen and methylcobalamin can be taken together and usually do not interact. Ibuprofen is a non-steroidal anti-inflammatory drug with antipyretic and analgesic properties, and can be used to relieve mild to moderate pain such as headache, arthralgia, and menstrual cramps, as well as fever caused by the common cold or influenza. Methylcobalamin is a neurotrophic drug that can be used in peripheral neuropathy, and in the treatment of megaloblastic anemia caused by vitamin B₁₂ deficiency. In general, methylcobalamin and ibuprofen can be taken together, usually do not produce drug interactions, patients should strictly follow the doctor’s instructions for the correct use of medication, do not change the dose of the drug or private abuse of the drug, for pregnant women, lactating women, and patients allergic to ibuprofen should be prohibited from the use of ibuprofen, methylcobalamin should not be used in methylcobalamin allergic patients.