Cholelithiasis is one of the common surgical diseases and its incidence has been on the rise in recent years. The cause of gallstone formation is very complex, the current medical community reached a consensus on the risk factors of gallstone disease (5F) include: obesity (fatty), family history (family history) high-fat diet (fatty meal), over forty years of age (forty), female (female); poor dietary habits and female pregnancy is also a high-risk factor for cholelithiasis. Can gallstones be dissolved? The so-called cholelithiasis medications often do not work well. In the United States, there have been clinical trials in which ten years of medication had no significant effect. What is the need for surgery? Symptomatic gallbladder stones require surgery. For asymptomatic so-called “quiescent” gallbladder stones, if the stone is single, directly larger than 5 millimeters, and the ducts of the gallbladder are not dilated, the patient can be followed up periodically for review. Surgery should be considered in elderly patients, women with many underlying diseases, or women who are planning to have children, even if they are asymptomatic, because the risk of emergency surgery for the first two is higher once acute attack is ineffective with conservative treatment, and the clinical treatment of the latter is greatly constrained if acute cholecystitis occurs during pregnancy due to fetal considerations. In addition, atrophic gallbladder with or without stones is an absolute indication for surgery. Isn’t the body missing an organ after gallbladder removal? The most important physiological function of the gallbladder is to concentrate bile. Concentrated bile can fully emulsify fats and proteins, which is more conducive to absorption in the small intestine. If we don’t have the gallbladder, the most obvious effect is the mild steatorrhea after eating in the early postoperative period, through dietary guidance, the vast majority of patients with diarrhea symptoms disappeared within 2 weeks. It is not that the gallbladder is cut, there is no gallbladder What will happen if we don’t do the surgery? Acute and chronic cholecystitis, gallbladder perforation, acute cholangitis, acute biliary pancreatitis, the most terrible thing is that it is closely related to gallbladder cancer. The proportion of gallbladder cancer combined with stones is 80%~100%; 1.5%~6.3% of patients with gallbladder stones develop gallbladder cancer; clinically, every 100 gallbladders resected will find 1 case of gallbladder cancer; the larger the gallbladder stones are, the higher the chances of developing gallbladder cancer. The risk of gallbladder cancer increases 10.1 times when the diameter of gallbladder stones is more than 3 centimeters than when the diameter is less than 1 centimeter, and the risk of gallbladder cancer is 29.9 times when the diameter of gallbladder stones is more than 1 centimeter than when there are no gallbladder stones.