If the headache is still there one week after pituitary tumor surgery, it is a common phenomenon if it is caused by surgical trauma. If the headache is caused by excessive loss of cerebrospinal fluid, hydrocephalus, or cerebral hemorrhage, it needs medical treatment. Pituitary tumor surgery belongs to craniotomy, during which the scalp and skull may be damaged. If there is no other problem, headache caused by surgical trauma only is a common phenomenon, which does not need to be handled, and the patient’s headache will be relieved after the wound heals. If the common phenomenon is excluded, the following situations need medical treatment. After pituitary tumor surgery, a drain will be placed in the cranium to drain the fluid, and if too much cerebrospinal fluid is drained, the intracranial pressure will be too low, resulting in low cranial pressure, which will cause headache. If hydrocephalus develops after surgery, the patient may have severe headache, projectile vomiting, and optic disk edema. If cerebral hemorrhage occurs after surgery, there may be headache with dizziness, unfavorable limb movement, and difficulty in comprehension. It is suggested that patients with headache one week after pituitary tumor surgery need to seek medical treatment in time, and the doctor will judge whether it is normal according to the cause and do the treatment accordingly.