Yellowish urine on Epalrestat may be caused by the effect of the drug itself, or by impaired liver or kidney function, and examination is recommended. Epalrestat is mainly used for the treatment of diabetic neuropathy, after using Epalrestat, the urine may appear reddish brown, if the color is lighter, yellowish brown, which is normal. However, Epalrestat may cause impaired liver and kidney function, resulting in yellowish urine. It is recommended to go to the hospital to check liver and kidney function and urine routine. Adverse reactions such as erythema, blisters, rash, elevated bilirubin, elevated alanine aminotransferase, diarrhea, nausea, vomiting, abdominal pain, and occasionally elevated creatinine may occur with Epalrestat. Pregnant women need to use the drug with caution, those who are allergic to Epalrestat, and breastfeeding women are prohibited from using the drug. The drug should be used under the supervision of a doctor, if there is any discomfort, the drug should be stopped and seek medical attention.