Metformin can be taken with Cagliflozin and should be used as prescribed. The main effect of metformin is to reduce fasting and postprandial blood glucose in diabetic patients by increasing the sensitivity of peripheral tissues to insulin. And Cagliflozin can reduce blood glucose by inhibiting SGLT2 to reduce renal reabsorption of filtered glucose and increase urinary glucose excretion. These two drugs have a synergistic effect, and taking them together can enhance the effect of lowering blood sugar. When metformin alone does not provide adequate glycemic control, cagliflozin can be used in combination with metformin, along with diet and exercise, to improve glycemic control in adults with type 2 diabetes mellitus. Common adverse reactions to metformin include gastrointestinal reactions, skin irritation, and lactic acidosis, and it is contraindicated in patients with severe comorbidities, alcoholism, and severe renal insufficiency. Complications such as genitourinary infections may occur with Cagliflozin, which is contraindicated in patients with severe infections, renal insufficiency, diabetic ketoacidosis, pancreatic insufficiency, and alcoholism. The drug should be used in accordance with medical advice.