Cholestasis can lead to gallbladder stones, inflammation of the biliary tract and other diseases, which can cause pain in the upper abdomen and pain in the region of the raphe, which can involve pain on the left side of the body, but mostly pain in the right upper abdomen of the body. 1. Gallbladder stones: the etiology is complex, factors affecting the ratio of cholesterol, bile acid and phospholipid concentration and causing cholestasis can form gallbladder stones. Typical symptoms are gallbladder colic, mostly occurring after meals, the pain is located in the right upper abdomen or epigastrium. Prolonged embeddedness causes gallbladder effusion, triggering pain in the whole abdomen, which may involve pain in the left half of the body. 2. Biliary tract inflammation: mainly cholecystitis and cholangitis in different parts. They are categorized into acute, subacute and chronic inflammation. The main causes are bile duct obstruction, bile stagnation, usually the right upper abdomen gallbladder region has pain. Inflammation spread to the plasma membrane may have abdominal muscle tension, rebound pain. If the gallbladder is encapsulated by the greater omentum, gangrene, perforation, etc. will cause diffuse peritonitis of the whole abdomen, then it will involve the left half of the body pain. If cholestasis causes discomfort, it is necessary to seek medical treatment as soon as possible to avoid complications.