Megakaryocyte maturation disorder is curable in some patients and difficult to cure in others. Megakaryocytes are the progenitor cells in the bone marrow that produce platelets, which can be formed when the edge of the megakaryocyte ruptures and falls off after maturation. Therefore, impaired maturation of megakaryocytes can cause thrombocytopenia, which is common in primary immune thrombocytopenia. 1. Some patients can be cured after treatment, and the treatment mode is related to the number of platelets. It mainly includes first-line treatment, second-line treatment and emergency treatment. (1) First-line treatment: glucocorticosteroids are preferred, such as prednisone and dexamethasone, with high efficiency. Intravenous gammaglobulin is also an option. (2) Second-line treatment: including thrombopoietin, immunosuppressants, such as vincristine, and splenectomy is also an option. (3) When platelets are very low, emergency treatment is needed, in which platelet transfusion is preferred, intravenous gammaglobulin, high-dose glucocorticoid shock therapy, plasma exchange, etc. can also be chosen. 2. If some patients are difficult to be cured after treatment, platelet transfusion can be given intermittently for supportive treatment. When patients have megakaryocyte maturation disorder, they should seek professional doctor’s consultation and treatment to avoid delaying and causing adverse consequences. The above drugs should be used under the guidance of a doctor.