There is a possibility that a lump in gluteal fasciitis could be diagnosed as cancer, but cancer is very unlikely, and there could be other causes. Gluteal fasciitis is mainly due to fatigue injury of the gluteal fascia resulting in aseptic inflammation, most often manifested as edema and pain in the gluteal muscles, usually confined to the periphery of the buttocks, and does not present with radiating pain with nerve compression symptoms. A small number of patients with gluteal fasciitis develop a mass, usually due to the repeated stimulation of aseptic inflammation caused by fibrous hyperplasia, the emergence of striated hard lumps. The disease of malignant tumor in hip mass is usually mainly originated from mesenchymal tissues, such as liposarcoma, fibrosarcoma, etc. In addition to causing pain and swelling in the buttocks, it will also cause nerve compression symptoms and systemic symptoms, such as radiating pain in the lower limbs, numbness, weakness, abnormalities in the function of the second bowel movement, low-grade fever, fatigue, emaciation, and other malignant fluid states. If gluteal fasciitis is diagnosed, early standardized treatment is recommended to reduce the adverse effects of the disease.