In the treatment of keratosis pilaris, antifungal and antikeratosis treatment is needed, and oral itraconazole capsule, combined with fluconazole capsule is needed. Before and after treatment, liver function tests should be performed regularly, and if there is any abnormality, oral glutathione and compound glycyrrhizin capsules should be taken. Topical application of naftifine ketoconazole ointment and bifonazole ointment is needed. Anti-cornification can choose to apply retinoic acid ointment, salicylic acid ointment, this drug and antifungal ointment 1:1 mixture of topical application, used and then wrapped in plastic wrap for local sealing treatment, to promote the full absorption of drugs. You can choose to soak your feet daily and gently rub the thickened areas with a foot stone in order to achieve the corresponding therapeutic effect.