Uniformity of liver parenchyma density is an imaging result obtained under ultrasound examination. Uniformity of liver parenchyma density indicates that the liver is generally normal in shape. Uneven hepatic parenchyma density is commonly seen in fatty liver or cirrhosis. If the patient is obese, there will be a large number of fat cells deposited in the liver, resulting in uneven hepatocytes on abdominal ultrasound or abdominal CT. In the case of chronic liver disease, such as viral hepatitis, autoimmune liver disease, alcoholic liver damage, etc., can lead to uneven liver density. Ultrasound, as a means of imaging, can be applied to the screening of many diseases and auxiliary diagnosis, and can determine whether there are any lesions in the organs in a more intuitive way, which is of high value in the clinic. However, any examination has its limitations, and the diagnosis of a disease does not rely solely on imaging, but also combines with other examination methods to make a comprehensive judgment. When the density of liver parenchyma changes, it is recommended to go to the hospital for further consultation, to clarify the cause of the disease, and then standardized treatment according to the doctor’s guidance.