Eye pain caused by sinusitis is usually not effectively treated with eye drops if it is involving pain. However, if the infection spreads and causes inflammation in the eye, patients can use eye drops as prescribed by their doctor to relieve eye discomfort. Sinusitis is possible to cause eye pain, sinusitis refers to the inflammation of the paranasal sinuses such as frontal sinus, pterygoid sinus, maxillary sinus, sieve sinus, etc., which occurs around the nasal cavity. Since the nose and eyes are innervated by the branches of the trigeminal nerves that innervate the local sensation, when the sinuses are inflamed, it is possible to cause ocular entrapment pain. Since the root cause of the lesion is not in the eye, the use of eye drops will not relieve the pain. However, if the inflammation in the nose spreads and causes inflammation in the eye, and the patient then develops eye pain, anti-inflammatory eye drops such as tobramycin eye drops and levofloxacin eye drops can be used as prescribed by the doctor to control the inflammation and alleviate the discomfort in the eye. It is recommended that patients with sinusitis consult a doctor in a timely manner to assess their condition and follow the doctor’s instructions for treatment to avoid delaying their condition.