Wake up at 3:00 to 4:00 in the morning, may be related to biological clock disorder, may also be due to neurasthenia, hyperthyroidism and other reasons. 1. Biological clock disorders: usually due to long-term irregular work and rest, regular excessive late night, resulting in biological clock disorders, resulting in sleep structure disorders, may cause three to four in the morning to wake up. 2. Neurasthenia: the disease is usually due to long-term mental stress, emotional over-anxiety, caused by long-term sleep disorders, due to long-term sleep disorders, the brain can not get enough rest, resulting in brain dysfunction, which may cause three to four in the morning to wake up, but also may be accompanied by difficulty in falling asleep, sleep during the process of dreaming and other symptoms. 3. Hyperthyroidism: The increased secretion of thyroid hormones in patients leads to increased basal metabolic rate and increased nerve excitability, which may lead to waking up at 3:00 am to 4:00 am, and may be accompanied by temper tantrums, hyperphagia, and weight loss. Waking up at three to four in the morning may also be caused by other reasons, if the symptoms persist, it should be taken seriously, go to the regular hospital as soon as possible, after clarifying the cause of the disease, give targeted treatment.