Thigh pain after walking for a long time may be related to muscle fatigue, hip joint lesions, lumbar lesions and other reasons. Walking time is too long thigh muscle fatigue, anaerobic fermentation occurs to produce lactic acid accumulation, there will be symptoms of thigh pain, usually after rest can be relieved. Hip joint lesions, such as hip joint effusion, ischemic necrosis of the femoral head, etc., walking too long will aggravate the inflammatory response of the hip joint, causing thigh pain. Lumbar lesions, such as lumbar disc herniation, spinal stenosis, lumbar spondylolisthesis, etc. Walking for too long, spinal nerve root compression will also have a certain impact on the thigh innervation function, soreness symptoms. If thigh pain occurs after walking for a long time, it is recommended that patients go to the hospital to improve the examination and receive regular treatment.