There is no most effective way to reduce blood creatinine value, and the methods to reduce blood creatinine include drug treatment and hemodialysis treatment. Elevated blood creatinine can be divided into physiological and pathological conditions. Physiological conditions include strenuous exercise, drinking a large amount of meat, etc., which will usually return to normal after removing the relevant factors; pathological conditions include acute and chronic renal failure, etc., and the common treatments include medication and hemodialysis treatment. 1. Drug treatment: If acute pre-renal renal failure causes elevated creatinine and the effective circulating blood volume is insufficient, the patient should be rehydrated in time; if post-renal renal failure causes elevated blood creatinine, such as stones, and if the stones are small, the patient should be treated with lithotripsy. Blood creatinine elevation caused by chronic renal failure, commonly used drugs include ACEI/ARB and other drugs. 2. Hemodialysis treatment: For severe pulmonary edema and acute left heart failure, hemodialysis or continuous renal replacement therapy is often needed to avoid delay. Preparation for renal replacement therapy is recommended for patients with chronic kidney disease stage 4 or above or those who are expected to require dialysis treatment within 6 months. Patients with elevated blood creatinine should go to the hospital in time for consultation, clarification of the cause of the disease under the guidance of specialized physicians, and timely treatment.