2 basic measures to reduce oral mucositis before and during radiotherapy: 1. Ensure optimal nutritional support during cancer treatment 2. Develop daily oral care habits: including soft-bristled toothbrush and mouth rinse These habits can reduce oral mucosal damage and provide nutritional assurance for mucosal repair Basic oral care measures: 1. General measures ① Check your oral mucosa daily ② Eliminate hidden problems that cause damage: such as ill-fitting dentures, splintered teeth ③ moisten your mouth and lips with lip balm (note: lip balm should not be used for a long time, lip balm can cause dehydration of mouth and lip cells) ④ drink more water to keep your mouth moist 2. brush teeth ① brush your teeth with soft bristles after each meal and before going to bed (remember: use a soft bristle toothbrush, a hard bristle toothbrush can damage your gums and cause bleeding), change your toothbrush every month ② brush your teeth with mild fluoride toothpaste ③ rinse your toothbrush after brushing and place it ④If you are used to flossing after meals to remove food between your teeth, please continue this habit, otherwise be careful to avoid damaging your gums. 3. After waking up in the morning and every time you brush your teeth, rinse with alcohol-free mouthwash, and then eat after 30 minutes of rinsing. 4. denture treatment ① remove the denture brush during oral care ② try to bring less denture before the oral mucosa damage heals, if conditions permit, try to put the denture in 0.2% chlorhexidine solution for 10 minutes after disinfection and then bring it on. 5. avoid stimulating pain ① avoid smoking, alcohol ② do not eat acidic, spicy, hot, hard food oral Preventive measures against mucositis I. Recommended measures: (strong evidence that the following measures are effective) 1. 30 minutes of ice in the mouth before 5-fluorouracil is flushed to prevent oral mucositis (Class II) 2. 3 days of recombinant human keratinocyte growth factor (dose: 60ug/kg/day) before high-dose chemotherapy, and 3 days after chemotherapy (Class II) 3. low-energy laser (wavelength: 650 nm, energy: 40 mW) 650 nm, energy 40 mW) to treat the oral cavity (Class II) 4, the use of “morphine” and other such painkillers to deal with intolerable pain caused by oral mucositis (Class II) 5, moderate dose of radiation therapy to the head and neck (50Gy), can contain gargle “Bendamycin “(also known as “inflammation pain static”) to prevent oral mucositis (Class I) 2. Before chemotherapy with high-dose “Marfalan”, “ice in the mouth” is recommended to prevent oral mucositis (Class III) 3, “Fentanyl transdermal patch and 0.2% morphine gargle can be used for pain relief of oral mucositis (Class III) 5. 6.Zinc supplementation before radiotherapy can reduce the occurrence of oral mucositis (Class III) 3.Not recommended measures (strong evidence: the following measures are not effective) 1.Not recommended to use “PTA tablets” (tablets containing: polymyxin, topomycin, amphotericin B) (containing: polymyxin, topomycin, amphotericin B) and “BcoG tablets” (containing: bacitracin, clotrimazole, gentamicin) are not recommended for the prevention of oral mucositis caused by head and neck radiotherapy (Class II) 2, “3. Intravenous “glutamine” is not recommended for the prevention of oral mucositis caused by high-dose chemotherapy ± systemic radiotherapy during bone marrow transplantation (Class II). IV. Not recommended measures (weak evidence of ineffectiveness of the following measures) 1. “GM-CSF” (granulocyte macrophage colony-stimulating factor) gargle is not recommended to prevent oral mucositis caused by high-dose chemotherapy during bone marrow transplantation (Class II) 3. 4.Pilocarpine is not recommended for oral prevention of oral mucositis caused by head and neck radiotherapy (Class III) and high-dose chemotherapy during bone marrow transplantation (Class II) Prevention and treatment of gastrointestinal mucositis I. Recommended measures (strong evidence of the effectiveness of the following measures) 1.Recommended use of aminoglutethimide (dosage: ≥340 mg/m2) for the prevention of radiation proctitis due to radiotherapy (Class II) 2. “Recommended measures (weaker evidence of the effectiveness of the following measures) 1. Amphotericin is recommended to prevent radiation esophagitis caused by radiotherapy for lung cancer (Class III) 2. “3. It is recommended to use “Salazosulfapyridine” (usage: 500 mg, orally, 2 times/day) to prevent radiation enteritis during pelvic radiotherapy (Category II) 4. 4. “Probiotics with Lactobacillus” is recommended to prevent diarrhea caused by chemotherapy and radiotherapy of pelvic tumors (Class III) 5. “Hyperbaric oxygen” is recommended to treat radiation proctitis (Class IV) 3. 2. “Methyl 5-acetylsalicylate” and its analogues “mesalazine” and “olsalazine” are not recommended for the prevention of gastrointestinal mucositis caused by radiotherapy (category I). “3. Misoprostol suppositories are not recommended for the prevention of acute radiation proctitis caused by radiotherapy for prostate cancer (Class I)