Left lower abdominal pain and pain site will move is mostly caused by irritable bowel syndrome, may also be the abdominal organs inversion of patients with acute appendicitis and other causes. 1. Irritable bowel syndrome (IBS): a disease characterized by abdominal pain, abdominal distension or abdominal discomfort with changes in bowel habits. Its main manifestation is abdominal pain or abdominal discomfort, the degree of abdominal pain is generally mild, the location is not certain, the lower abdomen and the left lower abdomen, can be accompanied by diarrhea, constipation, abdominal distension, fatigue, anxiety and other symptoms. It can lead to pain in the left lower abdomen and the site of pain will move. 2. Acute appendicitis in patients with inverted abdominal organs: inverted viscera is a rare congenital malformation, in which the internal organs are opposite to normal, and if acute appendicitis occurs in patients with inverted viscera, it can cause metastatic left lower abdominal pain, which leads to pain in the left lower abdomen and the site of the pain will move. It is usually accompanied by fever, abdominal distension, nausea and vomiting. There are many other causes of left lower abdominal pain with movement of the pain area, which should be taken seriously, and the cause of the pain should be identified and further management or treatment should be prescribed by the doctor.