Taking rabeprazole usually can’t check H. pylori, because it is easy to have false negative results, usually need to stop the drug for two weeks before checking. Rabeprazole is mainly used to protect the gastric mucosa and inhibit gastric acid secretion, which can inhibit H. pylori, and may cause H. pylori to produce spherical changes, resulting in false negatives. If checking H. pylori after taking rabeprazole is prone to false-negative results, leading to diagnostic errors and delayed treatment. Therefore, patients taking rabeprazole generally need to stop taking the drug for two weeks, waiting for no effect of the drug in the body before testing for H. pylori. H. pylori invades the human body and parasitizes the pylorus part of the stomach, and its long-term existence is likely to cause chronic gastritis, which can also lead to gastric ulcers or gastric atrophy, and in severe cases, develop into gastric cancer. Patients who are taking rabeprazole and need to be tested for H. pylori should promptly inform their doctor of all medications they have recently used, and then the doctor will decide whether it is appropriate to test and arrange a specific time for the test.