If a patient wakes up in the middle of the night with chest tightness and blockage, it is highly considered to be resting angina or caused by coronary artery vasospasm. Patients are advised to take sublingual medications to stop the uncomfortable symptoms, such as compound salvia drops or heart pills, and nitroglycerin is most effective if they can ensure that their blood pressure is not low. In addition, patients are advised to have their heart rate and blood pressure measured in a timely manner so that the severity of their current condition can also be assessed. Patients are advised to take a combination of drugs like bisoprolol and metoprolol to help improve myocardial ischemia and prevent the progression of painful symptoms. In addition, if the patient has hypertension, he can also take a combination of antihypertensive drugs. If the treatment at home is not effective, he should promptly go to the hospital for cardiac enzymes and electrocardiogram to clarify whether acute myocardial infarction has occurred.