Low reticulocytes are the same as high reticulocytes, and most are physiological in nature. If the reticulocyte count, especially the absolute count, is very significantly low, it is most often seen in bone marrow failure disorders, such as aplastic anemia. Other conditions, such as secondary bone marrow hematopoietic injury, can also cause low reticulocytes. There are also medications that can cause low reticulocytes. It is also important to be aware of low reticulocytes caused by radiation, such as some radiological examinations, such as X-rays and CT examinations, as well as the effects of hair dyes and food additives on hematopoiesis, which can also cause low reticulocytes. Most reticulocytes are physiological and should not be a cause for concern. In the case of pathological reticulocyte hypoplasia, if left undiagnosed and untreated, it can have serious consequences, such as causing aplastic anemia and leukemia.