The success of IVF is not only limited to the embryos being laid, but to bringing home a healthy baby. Many people think that the egg retrieval and transfer procedures are crucial in IVF treatment, but this is not the case. The egg retrieval and transfer procedures can be mastered with repeated practice, just like learning to swim or ride a bike. So what are the most critical factors for IVF success? 1. High quality embryos —- High quality eggs and sperm The prerequisite for obtaining high quality embryos is to obtain high quality eggs and sperm. The quality of eggs is first and foremost age related. Generally speaking, the younger the eggs are, the better the quality of the eggs. The ability to obtain the best quantity and quality of eggs at a given age of a woman depends to a large extent on the ovulation promotion protocol. Different infertile women have different age, ovarian reserve, weight and responsiveness to medications, which can lead to different ovulation protocols and different types and doses of medications used for ovulation promotion. The individualized ovulation protocols for infertile women at our center are designed according to each infertile woman’s special characteristics, so that she can achieve the optimal ovulation outcome. Sperm quality seems to be more influenced by male lifestyle, disease or genetics. Unhealthy lifestyles such as late nights, obesity, smoking and alcohol abuse, and hot work environments can cause sperm quality to decline. Certain diseases such as chromosomal abnormalities, missing Y chromosome segments, varicocele, rubella or juvenile mumps will cause male infertility. We currently assess male fertility by sperm count, morphology, viability and sperm DNA fragmentation index (DFI), of which DFI has the most predictive value and is closely related to embryonic developmental potential. For male patients undergoing IVF, we routinely assess these indicators and find that many infertile men have a high sperm DFI. When combined with medication through lifestyle modification, most men’s DFI indicators can decrease, which is quite beneficial for fertilization and embryo development. 2. A good endometrium —– is a suitable breeding ground for embryo implantation Successful embryo implantation is the result of a harmonious dialogue between the embryo and the endometrium. With quality embryos already in place, our focus is on the endometrium. If the endometrium is of good thickness and morphology, and blood flow is also rich, the success rate is higher after transferring a good quality embryo. What are the conditions in which the endometrium is not suitable for embryo implantation? Lesions of the endometrium, such as uterine polyps, submucosal fibroids, endometrial hyperplasia, endometritis, and uterine adhesions, may affect the embryo’s ability to find suitable soil for implantation. In addition, thin endometrium, poor blood flow to the endometrium, fluid in the fallopian tubes, and unsynchronized development of the endometrium and embryo may also affect embryo implantation. When this occurs, embryo transfer should be canceled and endometrial pathology should be treated first. If there are organic lesions in the endometrium, these lesions should be removed by surgical or pharmacological treatment before transfer. If the endometrium is very thin and medication cannot thicken it, the chances of conception can be increased by improving the endometrial blood flow. 3.Healthy body internal environment —- creates a good environment for fetal growth and development Embryo implantation into the endometrium is the first step to a successful pregnancy. To get a healthy baby, you need to let the fetus grow and develop healthily in the uterus. The baby gets its nutrients and oxygen from the mother’s blood exchange, so it is very important for the mother-to-be to have a healthy and balanced body for the baby’s development. Some of the more common disorders of the internal environment in women of childbearing age include: hyperprolactinemia, hyperandrogenemia, abnormal thyroid function, autoimmune diseases, abnormal coagulation, metabolic abnormalities, and bacterial infections. These abnormalities seem to be inextricably linked to infertility, spontaneous miscarriage or embryonic abortion. Correcting these abnormalities through lifestyle changes and medication before embryo transfer to provide a healthy and balanced developmental environment for the embryo will promote healthy growth of the baby and reduce complications during pregnancy and delivery. In addition to good physical condition, good psychological or mental condition is also very important. Bad emotions such as stress and anxiety may affect the development of follicles, and the body under stress may secrete certain harmful hormones that further disturb the homeostasis of the body. Therefore, it is important for people to maintain a relatively relaxed and happy state of mind during the treatment process, and to believe that they can get pregnant. Usually do something you like to divert your attention. When you have questions during the treatment, don’t hold back, we are always in the clinic and you can talk to us at any time. The embryo is equivalent to the seed, the endometrium is equivalent to the soil, and the internal environment of the woman’s body is the sun and the rain. When all these aspects are good, the wish to carry a healthy child home will surely come true!